Side effects of SNRIs (the main line of defense agaist neuropathic pain):
Duloxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
nausea
vomiting
constipation
diarrhea
heartburn
stomach pain
decreased appetite
dry mouth
increased urination
difficulty urinating
sweating or night sweats
dizziness
headache
tiredness
weakness
drowsiness
muscle pain or cramps
changes in sexual desire or ability
uncontrollable shaking of a part of the body
Some side effects can be serious. If you experience any of the following side effects, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately:
unusual bruising or bleeding
pain in the upper right part of the stomach
swelling of the abdomen
itching
yellowing of the skin or eyes
dark colored urine
loss of appetite
extreme tiredness or weakness
confusion
flu-like symptoms
fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness
blurred vision
fever
blisters or peeling skin
rash
hives
difficulty breathing or swallowing
swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
hoarseness
Side of marijuana (also used to treat neuropathic pain):
none